Polio, or more properly poliomyelitis, was one of the most feared and studied diseases of the first half of the 20th Century. Though the Salk and later the Sabin vaccines have essentially eliminated the disease in developed countries, many mysteries regarding polio remain. This is probably due to the fact that as polio epidemics ended in North America and Europe, research on the disease also came to an abrupt halt. Thus, as LaForce (1983) noted, knowledge about the epidemiology and pathology of polio is essentially frozen at a mid-1950s level. 


Poliomyelitis is an "inflammation of the gray matter of the spinal cord (Taber, 1970, p. P-77). Though the word "poliomyelitis" sounds complicated and impressive, it was formed by putting together the Greek words for the site of the disease - polios, meaning gray, myelos, meaning marrow, and adding the English suffix, itis, meaning inflammation. It has gone by many names including infantile paralysis, Heine-Medin's Disease, debility of the lower extremities, and spinal paralytic paralysis. In common usage, the term poliomyelitis is abbreviated to polio. 

Polio is caused by a virus which results in an acute infection. However, contrary to what is commonly believed, the virus did not typically result in paralysis. Rather, the majority of infected individuals experienced only mild respiratory or gastrointestinal symptoms, often accompanied by fever, headache, and muscle stiffness. These symptoms lasted only a few days, and many had such mild cases that they did not even realize they were ill. Therefore, they often continued on with there daily routines, attending school or work, and exposing many others to the polio virus. This fact helps explain the reports of many polio survivors that they were the only ones in their family, neighborhood, or community to have had polio. In actuality, there could have been many individuals with whom they came into contact who had the minor illness, as non-paralytic polio was often called. 

Only in a small number of cases did the virus penetrate the central nervous system, causing the major illness, or "true polio." In these cases, neurons (nerve cells) in the anterior horns of the spinal cord and the lower brain were affected, resulting in "tightness in the neck, back, and hamstring muscles as well as varying degrees of muscle weakness, as paralysis sets in" (Owen, 1990, p. 211). Though there was never a cure for polio, most who contracted it experienced improvement in muscle strength and control after the acute infection subsided. In some cases, however, motor neurons were left severely damaged or completely destroyed, resulting in permanent weakness or paralysis, most commonly to the lower extremities (Headley, 1995). 

There are actually three separate strains or immunologic types of the disease: Type I (Brunhide), Type II (Lansing), and Type III (Leon). Most epidemics, at least in the United States, were the result of Type I virus (Nathanson and Martin, 1979). 

The means by which the polio virus enters the central nervous system is still not definitely known. (Taber, 1970). However, it is interesting to note that relatively recent data from third-world nations suggests that when those experiencing acute polio are given injections such as DPT immunizations, antibiotics, antimalarials, or antipyretics, the injected limb develops paralysis within one week (LaForce, 1983).